适体
转铁蛋白受体
血脑屏障
受体
医学
双功能
癌症研究
药物输送到大脑
药物输送
药品
药理学
神经科学
化学
内科学
生物
中枢神经系统
生物化学
有机化学
催化作用
遗传学
作者
Joanna MacDonald,Giovanni Mandarano,Rakesh N. Veedu,Sarah Shigdar
摘要
Affecting approximately up to 10-40% of all cancer patients, the prognosis for patients suffering from metastatic brain tumours is poor. Treatment of these metastatic tumours is greatly hindered by the presence of the blood brain barrier which restricts the overwhelming majority of small molecules from entering the brain. A novel approach to overcome this barrier is to target receptor mediated transport mechanisms present on the endothelial cell membranes, in particular the transferrin receptor. Given their specificity, safety profile and stability, nucleic acid-based therapeutics are ideal for this purpose. This review explores the development of bifunctional aptamers for the treatment of brain metastases.
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