生物
同源重组
解旋酶
遗传学
DNA修复
背景(考古学)
基因组
减数分裂
微小染色体维持
计算生物学
DNA
真核细胞DNA复制
基因
核糖核酸
古生物学
作者
Wezley C. Griffin,Michael A. Trakselis
出处
期刊:DNA Repair
[Elsevier]
日期:2019-04-01
卷期号:76: 1-10
被引量:39
标识
DOI:10.1016/j.dnarep.2019.02.003
摘要
There are several DNA helicases involved in seemingly overlapping aspects of homologous and homoeologous recombination. Mutations of many of these helicases are directly implicated in genetic diseases including cancer, rapid aging, and infertility. MCM8/9 are recent additions to the catalog of helicases involved in recombination, and so far, the evidence is sparse, making assignment of function difficult. Mutations in MCM8/9 correlate principally with primary ovarian failure/insufficiency (POF/POI) and infertility indicating a meiotic defect. However, they also act when replication forks collapse/break shuttling products into mitotic recombination and several mutations are found in various somatic cancers. This review puts MCM8/9 in context with other replication and recombination helicases to narrow down its genomic maintenance role. We discuss the known structure/function relationship, the mutational spectrum, and dissect the available cellular and organismal data to better define its role in recombination.
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