The multifaceted role of autophagy in cancer

Review10 May 2022 The multifaceted role of autophagy in cancer Ryan C Russell Corresponding Author Ryan C Russell [email protected] orcid.org/0000-0003-3364-8869 Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada Center for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, ON, Canada Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada Search for more papers by this author Kun-Liang Guan Kun-Liang Guan orcid.org/0000-0003-1892-0174 Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA, USA Search for more papers by this author Ryan C Russell Corresponding Author Ryan C Russell [email protected] orcid.org/0000-0003-3364-8869 Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada Center for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, ON, Canada Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada Search for more papers by this author Kun-Liang Guan Kun-Liang Guan orcid.org/0000-0003-1892-0174 Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA, USA Search for more papers by this author Author Information Ryan C Russell *,1,2,3 and Kun-Liang Guan4 1Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada 2Center for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, ON, Canada 3Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada 4Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA, USA *Corresponding author. Tel: +1 613 562 5800; E-mail: [email protected] The EMBO Journal (2022)41:e110031https://doi.org/10.15252/embj.2021110031 This article is part of the Cancer Reviews series. Full textView the full text of the articlePDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Abstract Autophagy is a cellular degradative pathway that plays diverse roles in maintaining cellular homeostasis. Cellular stress caused by starvation, organelle damage, or proteotoxic aggregates can increase autophagy, which uses the degradative capacity of lysosomal enzymes to mitigate intracellular stresses. Early studies have shown a role for autophagy in the suppression of tumorigenesis. However, work in genetically engineered mouse models and in vitro cell studies have now shown that autophagy can be either cancer-promoting or inhibiting. Here, we summarize the effects of autophagy on cancer initiation, progression, immune infiltration, and metabolism. We also discuss the efforts to pharmacologically target autophagy in the clinic and highlight future areas for exploration. Previous ArticleNext Article Read MoreAbout the coverClose modalView large imageVolume 41,Issue 13,04 July 2022This cover highlights the article Gastric stem cells promote inflammation and gland remodeling in response to Helicobacter pylori via Rspo3‐Lgr4 axis by Jonas Wizenty, Michael Sigal and colleagues. H. pylori can colonize the progenitor and stem cell compartment deep in the gastric gland. These cells are uniquely equipped to sense H. pylori and initiate a selective response to the gland-invading bacteria, resulting in tissue remodelling and inflammation. The image displays hyperplastic gastric glands from mice infected for two months with H. pylori, the dividing Ki67* cells are stained in red, NF‐κB p65+ cells in green, gland base mucous cells in white, and DAPI+ cells in blue. (Scientific image by Jonas Wizenty, Charité – Universitätsmedizin Berlin, Germany) Volume 41Issue 134 July 2022In this issue RelatedDetailsLoading ...