免疫学
肺结核
结核分枝杆菌
NKG2D公司
潜伏性肺结核
表型
生物
自然杀伤细胞
医学
细胞毒性T细胞
体外
基因
病理
生物化学
作者
Yu Zhou,Haiping Lan,Hanlu Shi,Peihao Wu,Yonglie Zhou
出处
期刊:Tuberculosis
[Elsevier]
日期:2022-07-01
卷期号:135: 102221-102221
被引量:6
标识
DOI:10.1016/j.tube.2022.102221
摘要
Tuberculosis (TB) is a leading global public health problem; however, the mechanisms underlying the immunopathology of TB progression are not well understood. It is currently believed that Mycobacterium tuberculosis (Mtb) infection can modify natural killer (NK) cell phenotypic signatures. Hence, our study was designed to investigate the diversity of circulating NK cells in patients with different TB infection status. NK subsets, as well as their expression of activating and inhibitory receptors between active TB (ATB) and latent TB infection (LTBI) were evaluated. There were significant differences in NK cell phenotypes between ATB, LTBI and healthy controls. Notably, the proportion of KLRG1 in NK cells (P = 0.036), as well as in their subsets CD56DimCD16+ (P = 0.046) and CD27+ (P = 0.027) NK cells, increased significantly in LTBI group than in ATB group; while Mtb specific IFN-γ+CD56BrightCD16Dim NK cells expressed higher KLRG1 in ATB than in LTBI (P = 0.027). However, the expression of activating receptor NKG2D in NK subsets showed no significant difference among the study groups. Our results suggest that different TB infection status are coupled with the diversity of NK cell compartments, and the expression of KLRG1 in NK cells may be a specific phenotype that modulates the progression of TB from latent to active.
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