纳米载体
联合疗法
阿霉素
体内
紫杉醇
药理学
乳腺癌
材料科学
癌症研究
药品
癌细胞
癌症
医学
化疗
生物
内科学
生物技术
作者
Lupeng Zeng,Wanhua Shi,Huaying Wang,Xin Cheng,Tingting Chen,Liang Wang,Jianming Lan,Wei‐Ming Sun,Meicen Liu,Xi Zhang,Jing Zhang,Jinghua Chen
标识
DOI:10.1021/acsami.2c06546
摘要
To overcome the low efficacy of conventional monotherapeutic approaches that use a single drug, functional nanocarriers loaded with an amalgamation of anticancer drugs have been promising in cancer therapy. Herein, aloe-derived nanovesicles (gADNVs) are modified with an active integrin-targeted peptide (Arg-Gly-Asp, RGD) by the postinsertion technique to deliver indocyanine green (ICG) and doxorubicin (DOX) for efficient breast cancer therapy. We presented for the first time that the π-π stacking interaction can turn the "competitive" relationship of ICG and DOX inside gADNVs into a "cooperative" relationship and enhance their loading efficiency. The dual-drug codelivery nanosystem, denoted as DIARs, was well stable and leakproof, exhibiting high tumor-targeting capability both in vitro and in vivo. Meanwhile, this nanosystem showed significant inhibition of cell growth and migration and induced cell apoptosis with the combination of phototherapy and chemotherapy. Intravenous administration of DIARs exhibited high therapeutic efficacy in a 4T1 tumor-bearing mouse model and exhibited no obvious damage to other organs. Overall, our DIAR nanosystem constitutively integrated the natural and economical gADNVs, π-π stacking interaction based on efficient drug loading, and tumor-targeted RGD modification to achieve an effective combination therapy for breast cancer.
科研通智能强力驱动
Strongly Powered by AbleSci AI