计算生物学
基因组
集合(抽象数据类型)
蛋白质折叠
吸引子
计算机科学
蛋白质结构
序列(生物学)
蛋白质家族
折叠(DSP实现)
理论计算机科学
生物
基因
遗传学
数学
数学分析
生物化学
电气工程
程序设计语言
工程类
作者
Liisa Holm,Chris Sander
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1996-08-02
卷期号:273 (5275): 595-602
被引量:1453
标识
DOI:10.1126/science.273.5275.595
摘要
The comparison of the three-dimensional shapes of protein molecules poses a complex algorithmic problem. Its solution provides biologists with computational tools to organize the rapidly growing set of thousands of known protein shapes, to identify new types of protein architecture, and to discover unexpected evolutionary relations, reaching back billions of years, between protein molecules. Protein shape comparison also improves tools for identifying gene functions in genome databases by defining the essential sequence-structure features of a protein family. Finally, an exhaustive all-on-all shape comparison provides a map of physical attractor regions in the abstract shape space of proteins, with implications for the processes of protein folding and evolution.
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