体内分布
纳米探针
体内
聚乙二醇
单核吞噬细胞系统
材料科学
量子点
药代动力学
毒性
药理学
PEG比率
纳米技术
放射化学
医学
化学
纳米颗粒
病理
生物化学
内科学
生物
经济
生物技术
财务
作者
Yan Zhang,Yejun Zhang,Guosong Hong,Wei He,Kun Zhou,Kai Yang,Feng Li,Guangcun Chen,Zhuang Liu,Hongjie Dai,Qiangbin Wang
出处
期刊:Biomaterials
[Elsevier]
日期:2013-05-01
卷期号:34 (14): 3639-3646
被引量:225
标识
DOI:10.1016/j.biomaterials.2013.01.089
摘要
Ag2S quantum dots (QDs) have been demonstrated as a promising near-infrared II (NIR-II, 1.0–1.4 μm) emitting nanoprobe for in vivo imaging and detection. In this work, we carefully study the long-term in vivo biodistribution of Ag2S QDs functionalized with polyethylene glycol (PEG) and systematically examine the potential toxicity of Ag2S QDs over time. Our results show that PEGylated-Ag2S QDs are mainly accumulated in the reticuloendothelial system (RES) including liver and spleen after intravenous administration and can be gradually cleared, mostly by fecal excretion. PEGylated-Ag2S QDs do not cause appreciable toxicity at our tested doses (15 and 30 mg/kg) to the treated mice over a period of 2 months as evidenced by blood biochemistry, hematological analysis and histological examinations. Our work lays a solid foundation for further biomedical applications of Ag2S QDs as an important in vivo imaging agent in the NIR-II region.
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