基诺美
结直肠癌
癌症研究
酪氨酸激酶
计算生物学
生物
遗传学
激酶
癌症
受体
作者
Alberto Bardelli,D. Williams Parsons,Natalie Silliman,Janine Ptak,Steve Szabo,Saurabh Saha,Sanford D. Markowitz,James K.V. Willson,Giovanni Parmigiani,Kenneth W. Kinzler,Bert Vogelstein,Victor E. Velculescu
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2003-05-09
卷期号:300 (5621): 949-949
被引量:464
标识
DOI:10.1126/science.1082596
摘要
Tyrosine kinases (TKs) are central regulators of signaling pathways that control differentiation, transcription, cell cycle progression, apoptosis, motility, and invasion ( [1][1] ). Although a few TK genes have been shown to be mutationally altered in specific human cancers ( [1][1] ), it is not
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