黑色素瘤
MMP2型
MTT法
材料科学
细胞培养
免疫组织化学
细胞
化学
分子生物学
生物医学工程
病理
癌症研究
医学
生物
癌症
转移
生物化学
内科学
遗传学
作者
Bo Guo,B. Li,Xinlong Wang,M.X. Zhang,Naihong Yan,Xu Dong Zhang
出处
期刊:Key Engineering Materials
日期:2007-02-01
卷期号:330-332: 279-282
被引量:3
标识
DOI:10.4028/www.scientific.net/kem.330-332.279
摘要
The aim of this study is to reveal the response of highly malignant tumor cell to different hydroxyapatite particles. Human’s highly malignant melanoma (MM) cell line A875 is exposed to two kinds of short-rod hydroxyapatite particles. After incubated with hydroxyapatite particles at different time points, the effects of MM cell morphology, proliferation and invasion are evaluated by SEM, MTT, and MMP2 protein immunohistochemistry respectively. SEM figures show that superficial sentus of MM cells reduce; more secretion is found; and smaller HA particles have more obvious effect. At the same time, no statistic difference can be found in MTT assay and MMP2 expression measurement. This study also provides useful information about biosecurity of hydroxyapatite ceramic in transplantation after highly malignant tumor excision.
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