Nuclear PD-L1 regulates YAP-driven transcription via the PGE2-EP4-YAP-importin α3 axis in solid tumors

-EP4-YAP-importin-α3 axis as a key regulator of PD-L1 nuclear transport and YAP-driven transcriptional programs. Targeting this pathway may suppress nPD-L1- and Hippo-dependent tumor growth, offering a therapeutic strategy for cancers with elevated YAP activity.