生物
造血
干细胞
体细胞
人口
遗传学
突变体
髓样
核糖核酸
造血干细胞
细胞生物学
RNA结合蛋白
基因
突变
长非编码RNA
血细胞
小RNA
祖细胞
基因表达调控
细胞
免疫学
遗传变异
作者
Gaurav Agarwal,Mateusz Antoszewski,Xuejun Xie,Yash Pershad,Uma P. Arora,Chi-Lam Poon,Peng Lyu,Andrew J. Lee,Chunjie Guo,Tianyi Ye,Laila Barakat Norford,Anna‐Lena Neehus,Lucrezia della Volpe,Lara Wahlster,Diyanath Ranasinghe,Tzu-Chieh Ho,Trevor Barlowe,Arthur Chow,Alexandra Schurer,James Taggart
出处
期刊:Science
[American Association for the Advancement of Science]
日期:2026-01-01
卷期号:391 (6780): 52-58
被引量:4
标识
DOI:10.1126/science.adx4174
摘要
-mutant HSC clonal dominance. These findings leverage natural resilience to illuminate posttranscriptional regulation in human HSCs, suggesting that inhibition of MSI2 or its targets could be rational strategies for blood cancer prevention.
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