浆液性癌
沙粒体
浆液性液体
间变性淋巴瘤激酶
病理
BAP1型
旅客8
医学
核异型性
间皮瘤
卵巢癌
免疫组织化学
癌症
生物
内科学
基因
恶性胸腔积液
肺癌
转录因子
生物化学
作者
Pınar Bulutay,Doğan Vatansever,Ç. Taşkiran,Çisel Aydin Meriçöz,Fatma Tokat,Nilgün Kapucuoğlu,İbrahim Kulaç
出处
期刊:PubMed
日期:2023-04-20
卷期号:66 (2): 392-395
标识
DOI:10.4103/ijpm.ijpm_360_21
摘要
Malignant peritoneal mesothelioma (MPM) is an exceptionally rare tumor type. Although some somatic/germline genetic alterations including BAP1 loss have been identified in some cases, the molecular properties of MPMs are remained poorly understood. In recent years, anaplastic lymphoma kinase (ALK) gene rearrangement was revealed in a subset of (3.4%) MPMs. Low-grade serous carcinomas (LGSCs) are a rare subtype of ovarian carcinoma and have some morphologic and immunophenotypic overlapping features with MPMs and this may cause misdiagnosis in daily practice. Here, we report a case of 18-year-old women with STRN-ALK-rearranged MPM and no previous exposure to asbestos. This case was presented with bilateral pelvic masses and histologically was displaying pure papillary morphology with mild-to-moderate nuclear atypia, psammoma bodies, and diffuse PAX8 expression as LGSCs. With the detection of ALK alteration in some of the MPMs, a targeted treatment option has emerged for these unusual tumor types.
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