低蛋白血症
医学
倾向得分匹配
内科学
入射(几何)
回顾性队列研究
单变量分析
结直肠癌
混淆
腹部外科
外科
多元分析
癌症
光学
物理
作者
Bing Kang,Zhiqiang Zhao,Xiaoyu Liu,Yu-Xi Cheng,Wei Tao,Zheng-Qiang Wei,Dong Peng
标识
DOI:10.3389/fnut.2022.925086
摘要
Purpose The purpose of our study was to investigate the effect of pre-operative hypoalbuminemia on the short-term outcomes after primary colorectal cancer (CRC) surgery. Materials and methods The retrospective study enrolled CRC patients who underwent primary surgery from January 2011 to December 2021 in a single teaching hospital. The short-term outcomes were compared between the hypoalbuminemia group and the normal group using propensity score matching (PSM). Univariate and multivariate logistic regression analyses were used for analyzing independent predictors of overall complications and major complications. Results A total of 7,072 patients from a single center were enrolled in this study. There were 1,078 (15.2%) patients in the pre-operative hypoalbuminemia group and 5,994 (84.8%) patients in the normal pre-operative albumin group. After 1:1 PSM, there were 1,028 patients in the hypoalbuminemia group and 1,028 patients in the normal group. No significant differences were found in baseline information between the two groups after PSM. In terms of short-term outcomes, the hypoalbuminemia group had a longer operation time ( p = 0.003), greater volume of blood loss ( p = 0.036), longer hospital stays ( p < 0.01), higher proportion of overall complications ( p = 0.003), major complications ( p = 0.016), higher incidence of pneumonia and abdominal infection ( p = 0.001) than the normal group after PSM. Furthermore, hypoalbuminemia was an independent predictor for overall complications ( p = 0.008) and major complications ( p = 0.016). Conclusion Pre-operative hypoalbuminemia increased overall complications and major complications after primary CRC surgery. Furthermore, hypoalbuminemia was an independent predictor for overall complications and major complications.
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