化学
吡唑
异构化
三氟甲基
废止
区域选择性
组合化学
级联
级联反应
双键
环加成
立体化学
有机化学
催化作用
色谱法
烷基
作者
Yu Sun,Zhen Yang,Shu-Ning Lu,Zhengkai Chen,Xiao‐Feng Wu
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-09-09
卷期号:24 (37): 6822-6827
被引量:18
标识
DOI:10.1021/acs.orglett.2c02746
摘要
A straightforward strategy for the metal-free construction of trifluoromethyl-containing pyrazole derivatives has been achieved from readily available α-halo hydrazones and CF3-imidoyl sulfoxonium ylides. The cascade transformation proceeds through the formal [4+1] cycloaddition followed by an unexpected dual double bond isomerization. The protocol features mild conditions, easy operation, excellent substrate compatibility, and good regioselectivity. The synthetic utility is demonstrated by scale-up reaction and further elaboration of the obtained pyrazole products.
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