蛋氨酸
免疫
去甲基化
DNA去甲基化
染色质
生物
癌症研究
生物化学
化学
免疫系统
DNA
遗传学
DNA甲基化
基因
氨基酸
基因表达
作者
Fangchao Wei,Jason W. Locasale
标识
DOI:10.1016/j.trecan.2023.07.008
摘要
Fang et al. recently reported in Cancer Cell that methionine restriction increases antitumor immunity by enhancing cyclic GMP-AMP synthase (cGAS) activity and promoting its dissociation from chromatin. This finding identifies a potential strategy to target cGAS demethylation in cancer therapy by altering methionine metabolism.
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