神经退行性变
视网膜
视网膜变性
视网膜
炎症
黄斑变性
胶质增生
生物
调节性T细胞
视网膜色素上皮
免疫学
神经科学
疾病
医学
病理
免疫系统
眼科
T细胞
白细胞介素2受体
生物化学
作者
María Llorián-Salvador,Alerie Guzman de la Fuente,Christopher E McMurran,Rosana Peñalva,Yvonne Dombrowski,Alan W. Stitt,Denise Fitzgerald
标识
DOI:10.1101/2023.10.11.561874
摘要
Abstract Aging is the principal risk factor for retinal degenerative diseases, which are the commonest cause of blindness in the developed countries. These conditions include age-related macular degeneration or diabetic retinopathy. Regulatory T cells play a vital role in immunoregulation of the nervous system by limiting inflammation and tissue damage in health and disease. Because the retina was long-considered an immunoprivileged site, the precise contribution of regulatory T cells in retinal homeostasis and in age-related retinal diseases remains unknown. Our study shows that regulatory T cell elimination leads to retinal pigment epithelium cell dysmorphology, and accumulation of phagocytes in the subretinal space of young and aged mice. However, only aged mice experience retinal neurodegeneration and gliosis. Surprisingly, adoptive transfer of young but not aged regulatory T cells reverse these changes. This study reveals a previously unknown protective role of regulatory T cells in maintaining aged retinal homeostasis.
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