下调和上调
安普克
癌细胞
癌症干细胞
癌症
干细胞
肿瘤微环境
肿瘤进展
生物
癌症研究
细胞生物学
蛋白激酶A
激酶
生物化学
基因
遗传学
肿瘤细胞
作者
Arin Nam,Shashi Jain,Chengsheng Wu,Alejandro D. Campos,Ryan M. Shepard,Ziqi Yu,Joshua P. Reddy,Tami Von Schalscha,Sara M. Weis,Mark W. Onaitis,Hiromi I. Wettersten,David A. Cheresh
出处
期刊:Cancer Research
[American Association for Cancer Research]
日期:2024-04-08
卷期号:84 (10): 1630-1642
被引量:17
标识
DOI:10.1158/0008-5472.can-23-2700
摘要
Upregulation of integrin αvβ3, a cancer stem cell marker, in response to nutrient stress activates sustained AMPK/PGC1α signaling that induces metabolic reprogramming in lung cancer cells to support their survival. See related commentary by Rainero, p. 1543.
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