化学
喹啉酮
催化作用
小学(天文学)
脱羧
酰胺
组合化学
杂原子
原子经济
催化循环
表面改性
序列(生物学)
立体化学
药物化学
有机化学
戒指(化学)
物理
物理化学
天文
生物化学
作者
Xuan Wu,Weiping Wu,Shuaixin Fan,Xuanzhen Han,Zhixin Wang,Hanxiao Xu,Baochen Wang,Jin Zhu
摘要
Multi-heteroatom heterocycle synthesis through direct C-H bond activation is methodologically appealing but synthetically challenging. An efficient double C-N bond formation sequence to prepare quinazolinones utilizing primary amides and oxadiazolones in a catalytic redox-neutral [CoCp*(CO)I2]/AgSbF6 system, where oxadiazolone could function as an internal oxidant to maintain the catalytic cycle, is reported. Amide-directed C-H bond activation and oxadiazolone decarboxylation are key to the success of this traceless, atom- and step-economic, and cascade approach for the construction of the quinazolinone skeleton.
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