溶瘤病毒
医学
临床试验
药物输送
免疫系统
单核吞噬细胞系统
癌症
药品
机制(生物学)
癌症治疗
纳米技术
免疫学
药理学
内科学
哲学
材料科学
认识论
作者
Mobarakeh Ajam-Hosseini,Fatemeh Akhoondi,Mohammad Doroudian
标识
DOI:10.1016/j.critrevonc.2023.103980
摘要
Oncolytic viruses (OV) are an attractive prospect due to their dual attack mechanism of direct cell lysis and potentiation of an antitumor immune response. Various oncolytic viral vectors are used in oncotherapy clinical trials, and one of their main problems is elimination by the reticuloendothelial system during systemic delivery. Nanoparticles (NPs) have received much attention in clinical trials due to their unique appearance characteristics, but they have created challenges due to the non-specificity of drug delivery to the target tissue and its elimination in blood circulation. In this regard, to increase the efficiency of nanoparticles in drug delivery, various chemical modifications can be applied to the surface of nanoparticles. To improve the performance of these two treatment options, the complex strategy of OVs encapsulated with nanoparticles can be used, which has brought successful clinical results in the treatment of various cancers. Here we will review each of the treatment methods and their functional mechanism.
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