生物
自噬
细胞生物学
微管
死孢子体1
MDA5型
病毒学
遗传学
RNA干扰
核糖核酸
基因
细胞凋亡
作者
Zhuang Li,Ying–Cheng Lai,Runhui Qiu,Wanhu Tang,Jie Ren,Shaobo Xiao,Puxian Fang,Liurong Fang
摘要
Coronavirus nsp8, a component of the viral replication transcriptional complex, is well conserved and plays a crucial role in viral replication. Exploration of the role mechanism of nsp8 is conducive to the understanding of viral pathogenesis and development of anti-viral strategies against coronavirus. Here, we found that nsp8 of PDCoV, an emerging enteropathogenic coronavirus with a zoonotic potential, is an interferon antagonist. Further studies showed that PDCoV nsp8 interacted with MDA5 and sequestosome 1/p62, promoting p62-mediated selective autophagy to degrade MDA5. We further found that PDCoV nsp8 could induce hyperacetylation of MT, therefore triggering selective autophagic degradation of MDA5 and inhibiting IFN-β production. These findings reveal a novel immune evasion strategy used by PDCoV nsp8 and provide insights into potential therapeutic interventions.
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