医学
离格
胰腺癌
免疫系统
癌症
肿瘤科
免疫疗法
胰腺导管腺癌
化疗
疾病
内科学
癌症研究
免疫学
放射治疗
作者
Suna Erdem,Jayanth S. Shankara Narayanan,Mathias Worni,Martin Bolli,Rebekah R. White
出处
期刊:Heliyon
[Elsevier]
日期:2024-01-01
卷期号:10 (1): e23551-e23551
标识
DOI:10.1016/j.heliyon.2023.e23551
摘要
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease, projected to rank as the second most prevalent cause of cancer-related mortality by 2030. Despite significant progress in advances in surgical techniques and chemotherapy protocols, the overall survival (OS) remains to be less than 10 % for all stages combined.In recent years, local ablative techniques have been introduced and utilized as additional therapeutic approaches for locally advanced pancreatic cancer (LAPC), with promising results with respect to local tumor control and OS. In addition to successful cytoreduction, there is emerging evidence that local ablation induces antitumor immune activity that could prevent or even treat distant metastatic tumors. The enhancement of antitumor immune responses could potentially make ablative therapy a therapeutic option for the treatment of metastatic PDAC. In this review, we summarize current ablative techniques used in the management of LAPC and their impact on systemic immune responses.
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