四斯潘宁
长寿
生物
细胞生物学
遗传适应性
基因
遗传学
细胞
作者
Wen Jiang,Henry De Belly,Bingying Wang,Andrew Wong,M. Yvonne Kim,Fiona Oh,Joseph J. DeGeorge,Xinya Huang,Shouhong Guang,Orion D. Weiner,K. Dengke
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2024-01-26
卷期号:10 (4)
标识
DOI:10.1126/sciadv.adj3880
摘要
Early-life stress experiences can produce lasting impacts on organismal adaptation and fitness. How transient stress elicits memory-like physiological effects is largely unknown. Here, we show that early-life thermal stress strongly up-regulates tsp-1 , a gene encoding the conserved transmembrane tetraspanin in C. elegans . TSP-1 forms prominent multimers and stable web-like structures critical for membrane barrier functions in adults and during aging. Increased TSP-1 abundance persists even after transient early-life heat stress. Such regulation requires CBP-1, a histone acetyltransferase that facilitates initial tsp-1 transcription. Tetraspanin webs form regular membrane structures and mediate resilience-promoting effects of early-life thermal stress. Gain-of-function TSP-1 confers marked C. elegans longevity extension and thermal resilience in human cells. Together, our results reveal a cellular mechanism by which early-life thermal stress produces long-lasting memory-like impact on organismal resilience and longevity.
科研通智能强力驱动
Strongly Powered by AbleSci AI