等离子体电解氧化
血管生成
材料科学
脐静脉
涂层
钛
电解质
兴奋剂
化学工程
冶金
纳米技术
癌症研究
生物化学
电极
生物
化学
体外
物理化学
工程类
光电子学
作者
Bowei Liang,Fasheng Wang,Yaoyu Qiu,Yao-Qing Chen,Yun Xie
标识
DOI:10.1016/j.matlet.2022.133593
摘要
Vessel formation is crucial for bone remodeling process. In this study, we fabricated a selenium (Se) incorporated plasma electrolytic oxidation (PEO) coating on titanium (Ti) surface and its influence on the angiogenesis behaviors of human umbilical vein endothelial cells (HUVECs) were investigated. The Se-doped PEO coating exhibited a porous morphology and a sustained low does release of Se ions. Although the cells cultured on the coated Ti showed few differences in proliferation comparing to uncoated Ti, the cells exhibited a higher migration ratio and up-regulated angiogenesis-related genes (including KDR, VEGF, and HIF-α). Therefore, the Se-doped PEO coating provides a new strategy to enhance vascularization surrounding the bone and thus facilitating bone regeneration after implantation.
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