Se-doped plasma electrolytic oxidation coating enhances angiogenesis induction performance of Ti implant

Vessel formation is crucial for bone remodeling process. In this study, we fabricated a selenium (Se) incorporated plasma electrolytic oxidation (PEO) coating on titanium (Ti) surface and its influence on the angiogenesis behaviors of human umbilical vein endothelial cells (HUVECs) were investigated. The Se-doped PEO coating exhibited a porous morphology and a sustained low does release of Se ions. Although the cells cultured on the coated Ti showed few differences in proliferation comparing to uncoated Ti, the cells exhibited a higher migration ratio and up-regulated angiogenesis-related genes (including KDR, VEGF, and HIF-α). Therefore, the Se-doped PEO coating provides a new strategy to enhance vascularization surrounding the bone and thus facilitating bone regeneration after implantation.