P23 | Determination of N‐acetylcysteine in chicken plasma by LC–MS/MS analysis

Data on antimicrobial prescriptions were obtained via export from the VTH management software.Results: A total of 265 antimicrobial prescriptions were written; in 232 cases (88%) antimicrobials were prescribed in monotherapy, in 3 (1%) in fixed dose combination (two or more drugs are combined in one product) and in one product and in 30 (11%) in empirical combinations.Ten different classes for a total of 295 antimicrobials, were prescribed.Amoxicillin/clavulanic acid (n = 166, 56%), fluoroquinolones (n = 77, 26%) and tetracyclines (n = 17, 6%) were the antimicrobial classes most prescribed.A total of 91 (31% of all antimicrobials)were Highest Priority Critically Important Antimicrobials (HPCIAs).Fluoroquinolones represented the large majority (85%) of the HPCIAs, followed by last generation cephalosporins (7%), lincosamides (5%) and polymyxins (3%).Only 21 antimicrobial prescriptions (8%) were supported by culture and susceptibility tests (CST).This rose to only 12% when HPCIAs were prescribed. Conclusions:The results of the present study are in line with those of similar studies in terms of antimicrobial prescribing attitudes.The study highlights a relevant use of HPCIAs that, in consideration of the scarce use of CTS, should be considered largely empirical.The implementation of policy to reduce the use of HPCIAs and interventions to increase the use of CST represents a priority to improve the appropriateness of use of antimicrobial in cat practice at the VTH of the University of Pisa.