壳聚糖
涂层
聚电解质
化学
抗菌剂
双层
聚合物
碳酸
化学工程
透明质酸
吸附
材料科学
有机化学
膜
生物化学
生物
工程类
遗传学
作者
Ivan S. Chaschin,Maria A. Sinolits,G. A. Badun,Maria G. Chernysheva,Nelya M. Anuchina,Sergey V. Krasheninnikov,Г.А. Хугаев,Antonina A. Petlenko,Д.В. Бритиков,А.В. Зубко,Alexey D. Kurilov,Elizabet I. Dreger,Natalia P. Bakuleva
标识
DOI:10.1016/j.ijbiomac.2022.10.056
摘要
The tightly bonded shielding coating on biomatrix significantly enhances the functionality of medical devices, bioprostheses in particular. In our work we have obtained a polyelectrolyte coating on a biomatrix by sequentially depositing chitosan and hyaluronic acid (HA) from solutions in carbonic acid under pressure. This approach makes it possible to obtain hybrid biomatrix with a firmly bonded polymer screen due to the electrostatic bonding of polyions. High-precision analysis using a tritium label shows a 3-fold increase in quantity of HA in carbonic acid under pressure compared to the conventional method. The presence of the chitosan layer increases the HA adsorption by 15-20 % due to electrostatic interaction of differently charged polymers. Antimicrobial results show the possibility of implementing an induced antimicrobial response, due to the lysis of the upper layer of the coating (HA) and the release of antimicrobial agents in the case of growth of pathogens on the bioprosthesis.
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