生物
相互作用体
蛋白酶体
细胞生物学
内质网相关蛋白降解
蛋白质稳态
转录因子
硒蛋白P
计算生物学
未折叠蛋白反应
遗传学
生物化学
基因
内质网
酶
谷胱甘肽
谷胱甘肽过氧化物酶
作者
Farid Ghelichkhani,Fabio González,Mariia A. Kapitonova,Stephanie A. Schaefer-Ramadan,Jun Li,Rujin Cheng,Sharon Rozovsky
标识
DOI:10.1016/j.abb.2022.109427
摘要
Selenoprotein S (selenos) is a small, intrinsically disordered membrane protein that is associated with various cellular functions, such as inflammatory processes, cellular stress response, protein quality control, and signaling pathways. It is primarily known for its contribution to the ER-associated degradation (ERAD) pathway, which governs the extraction of misfolded proteins or misassembled protein complexes from the ER to the cytosol for degradation by the proteasome. However, selenos's other cellular roles in signaling are equally vital, including the control of transcription factors and cytokine levels. Consequently, genetic polymorphisms of selenos are associated with increased risk for diabetes, dyslipidemia, and cardiovascular diseases, while high expression levels correlate with poor prognosis in several cancers. Its inhibitory role in cytokine secretion is also exploited by viruses. Since selenos binds multiple protein complexes, however, its specific contributions to various cellular pathways and diseases have been difficult to establish. Thus, the precise cellular functions of selenos and their interconnectivity have only recently begun to emerge. This review aims to summarize recent insights into the structure, interactome, and cellular roles of selenos.
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