Consolidative thoracic radiotherapy in the immunotherapy era for extensive-stage small cell lung cancer: a systematic review and meta-analysis with emphasis on brain and liver metastases

cTRT confers significant improvements in OS and PFS in the general population of patients with ES-SCLC, as well as in patients with baseline brain metastasis. Moreover, cTRT may be associated with prolonged BMFS, potentially reflecting an abscopal effect. The safety profile remains acceptable, given the substantial survival benefit.