亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Platelets and platelet adhesion molecules: novel mechanisms of thrombosis and anti-thrombotic therapies

止血 全球生产总值 医学 血小板 血栓形成 凝结 血小板活化 凝血酶 药理学 内科学 免疫学
作者
Xiaohong Xu,Naadiya Carrim,Miguel A. D. Neves,Thomas McKeown,Tyler W. Stratton,Rodrigo Coelho,Xi Lei,Pingguo Chen,Jianhua Xu,Xiangrong Dai,Benjamin Xiaoyi Li,Heyu Ni
出处
期刊:Thrombosis Journal [BioMed Central]
卷期号:14 (S1) 被引量:176
标识
DOI:10.1186/s12959-016-0100-6
摘要

Platelets are central mediators of thrombosis and hemostasis. At the site of vascular injury, platelet accumulation (i.e. adhesion and aggregation) constitutes the first wave of hemostasis. Blood coagulation, initiated by the coagulation cascades, is the second wave of thrombin generation and enhance phosphatidylserine exposure, can markedly potentiate cell-based thrombin generation and enhance blood coagulation. Recently, deposition of plasma fibronectin and other proteins onto the injured vessel wall has been identified as a new "protein wave of hemostasis" that occurs prior to platelet accumulation (i.e. the classical first wave of hemostasis). These three waves of hemostasis, in the event of atherosclerotic plaque rupture, may turn pathogenic, and cause uncontrolled vessel occlusion and thrombotic disorders (e.g. heart attack and stroke). Current anti-platelet therapies have significantly reduced cardiovascular mortality, however, on-treatment thrombotic events, thrombocytopenia, and bleeding complications are still major concerns that continue to motivate innovation and drive therapeutic advances. Emerging evidence has brought platelet adhesion molecules back into the spotlight as targets for the development of novel anti-thrombotic agents. These potential antiplatelet targets mainly include the platelet receptors glycoprotein (GP) Ib-IX-V complex, β3 integrins (αIIb subunit and PSI domain of β3 subunit) and GPVI. Numerous efforts have been made aiming to balance the efficacy of inhibiting thrombosis without compromising hemostasis. This mini-review will update the mechanisms of thrombosis and the current state of antiplatelet therapies, and will focus on platelet adhesion molecules and the novel anti-thrombotic therapies that target them.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
2秒前
16秒前
23秒前
科研通AI5应助Hung采纳,获得10
58秒前
1分钟前
yyy发布了新的文献求助10
1分钟前
1分钟前
Titi发布了新的文献求助10
1分钟前
mcs完成签到,获得积分10
1分钟前
单薄乐珍完成签到 ,获得积分0
1分钟前
bkagyin应助yyy采纳,获得10
1分钟前
1分钟前
动漫大师发布了新的文献求助10
1分钟前
mcs发布了新的文献求助10
1分钟前
2分钟前
Whassupww完成签到,获得积分10
2分钟前
2分钟前
Iron_five完成签到 ,获得积分10
2分钟前
俏皮的安萱完成签到 ,获得积分10
2分钟前
abcdefg完成签到 ,获得积分10
2分钟前
柒咩咩完成签到 ,获得积分10
2分钟前
科研通AI2S应助VDC采纳,获得10
3分钟前
恋恋青葡萄完成签到,获得积分10
3分钟前
开心的桔子完成签到 ,获得积分10
3分钟前
3分钟前
zht完成签到,获得积分10
3分钟前
会科研的胡萝卜完成签到,获得积分10
4分钟前
在水一方应助coco采纳,获得10
4分钟前
娜娜子完成签到 ,获得积分10
4分钟前
4分钟前
4分钟前
coco发布了新的文献求助10
4分钟前
龙牙发布了新的文献求助10
4分钟前
3113129605完成签到 ,获得积分10
4分钟前
Leif完成签到 ,获得积分0
4分钟前
清秀的懿轩完成签到 ,获得积分10
4分钟前
Xiaoxiao应助expoem采纳,获得10
4分钟前
4分钟前
5分钟前
高分求助中
【此为提示信息,请勿应助】请按要求发布求助,避免被关 20000
Les Mantodea de Guyane Insecta, Polyneoptera 2500
Computational Atomic Physics for Kilonova Ejecta and Astrophysical Plasmas 500
Technologies supporting mass customization of apparel: A pilot project 450
Brain and Heart The Triumphs and Struggles of a Pediatric Neurosurgeon 400
Cybersecurity Blueprint – Transitioning to Tech 400
Mixing the elements of mass customisation 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3782649
求助须知:如何正确求助?哪些是违规求助? 3328049
关于积分的说明 10234269
捐赠科研通 3043003
什么是DOI,文献DOI怎么找? 1670433
邀请新用户注册赠送积分活动 799680
科研通“疑难数据库(出版商)”最低求助积分说明 758971