Survival analysis of low-grade glioma treated by postoperative radiotherapy

OBJECTIVE: To retrospectively analyze the 3-year survival rate and factors of low-grade glioma treated by postoperative radiotherapy.METHODS: The data of 101 patients with LGG treated by postoperative radiotherapy were retrospectively analyzed.Forty-four patients received total resection,57 received subtotal resection,including 60 patients had chemotherapy.The median waiting time from operation to radiotherapy was 24 days,and the radiation dose was between 40 and 60 Gy.The survival rate was caculated by K-M,the Log-rank was used for univariate analysis,and Cox model was used for multivariate analysis.RESULTS: The 1-year and 3-year overall survival rates were 91% and 70% respectively.Univariate analysis showed: KPS score(P=0.01),tumor size(P=0.002),the extent of surgical resection(P0.000),the dose of radiotherapy(P=0.008),age(P0.000),and whether the combination chemotherapy was(P=0.007) were important factors affecting the 3-year survival rate.Multivariate analysis showed that KPS score before radiotherapy(P=0.034),the extent of surgical resection(P=0.001),radiotherapy dose(P=0.013),and age(P0.000) were the independent factors affecting the 3-year survival rate of low-grade glioma treated by postoperative radiotherapy.The impact of the surgery methods on 3-year survival rate was greater than the impact of radiation dose on it(P0.05).CONCLUSION: Age40 years,KPS before radiotherapy≥70,total resection and radiation dose between 54 and 60 Gy are the better factors.