Cover Picture: Sandmeyer‐Type Trifluoromethylthiolation and Trifluoromethylselenolation of (Hetero)Aromatic Amines Catalyzed by Copper (Chem. Eur. J. 1/2016)

The late-stage introduction of trifluoromethylthio and trifluoromethylseleno groups is of high interest for drug discovery, because these moieties sharply increase the lipophilicity and membrane permeability of bioactive compounds, thus increasing their bioavailability. Straightforward methods to introduce these important moieties, starting from easily available precursors, are disclosed. The key advantages of the Sandmeyer process are its mild reaction conditions, the use of an inexpensive copper catalyst, and the exceptional functional group tolerance. More information can be found in the Communication by L. J. Gooßen et al. on page 79 ff. The late-stage introduction of trifluoromethylthio and trifluoromethylseleno groups is of high interest for drug discovery, because these moieties sharply increase the lipophilicity and membrane permeability of bioactive compounds, thus increasing their bioavailability. Straightforward methods to introduce these important moieties, starting from easily available precursors, are disclosed. The key advantages of the Sandmeyer process are its mild reaction conditions, the use of an inexpensive copper catalyst, and the exceptional functional group tolerance. More information can be found in the Communication by L. J. Gooßen et al. on page 79 ff.