遗传增强
基因
生物
裸DNA
病毒载体
载体(分子生物学)
基因治疗载体
计算生物学
人口
基因转移
DNA
遗传学
医学
重组DNA
环境卫生
作者
Guofeng Zhang,Vladimir G. Budker,James J. Ludtke,Jon A. Wolff
出处
期刊:Humana Press eBooks
[Humana Press]
日期:2004-02-17
卷期号:: 251-264
被引量:4
标识
DOI:10.1385/1-59259-649-5:251
摘要
Gene therapy—the goal of which is to cure inheritable and acquired diseases by supplying genetic information to various tissues—is a promising therapy of the new millennium. To date, many strategies have been attempted to cure a disease by adding a foreign gene or correcting a mutation in the genes. The success of these gene-therapy strategies is largely dependent on the development of a vector that delivers and efficiently expresses a therapeutic gene in a specific cell population. Viral vectors are potentially efficient, although nonviral vectors have some advantages in that they are typically less immunogenic and easier to prepare. Direct, nonviral gene transfer into the whole organism remains a desirable goal for gene therapy because it avoids laborious and costly cell culture; the gene could be administered as easily as a drug.
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