Distinguishing cytomegalovirus meningoencephalitis from other viral central nervous system infections

医学 病毒性脑膜炎 脑膜脑炎 脑炎 红细胞增多 水痘带状疱疹病毒 肠道病毒 脑脊液多细胞增多 病毒性脑炎 病毒学 单纯疱疹病毒 脑膜炎 巨细胞病毒 病因学 无菌性脑膜炎 免疫学 病毒 疱疹病毒科 病毒性疾病 病理 儿科 细菌性脑膜炎
作者
Guy Handley,Stephanie Pankow,Jennifer Dien Bard,Rebecca Yee,Masayuki Nigo,Rodrigo Hasbun
出处
期刊:Journal of Clinical Virology [Elsevier BV]
卷期号:142: 104936-104936 被引量:24
标识
DOI:10.1016/j.jcv.2021.104936
摘要

Hallmarks of cytomegalovirus (CMV) meningoencephalitis include fever, altered mental status, or meningismus with pleocytosis, elevated protein and hypoglycorrhachia on cerebrospinal fluid (CSF) analysis. Magnetic resonance imaging may show ventriculitis, ependymitis or periventricular enhancement. Studies are limited comparing clinical and laboratory characteristics to other viral etiologies.This multi-center, retrospective cohort analysis reviewed patients with CMV meningitis or encephalitis and compared clinical features, laboratory findings and outcomes to the most common viral causes of meningoencephalitis.Patients with encephalitis or aseptic meningitis and detectable genetic material by polymerase chain reaction were identified. Clinical characteristics, laboratory findings and neuroimaging were collected from the electronic medical record. Data analysis was performed comparing CMV to other viral etiologies.485 patients were evaluated and included cases of CMV (n = 36) which were compared with herpes simplex virus (n = 114), enterovirus (n = 207), varicella zoster virus (n = 41) and West Nile virus (n = 81). Human immunodeficiency virus (HIV) infection was seen more frequently in CMV infection compared with all other viral etiologies. Clinical presentations and CSF findings of other viral etiologies differ compared with CMV. Hypoglycorrhacia occurred more often with CMV compared with other viral pathogens. Outcomes were significantly worse compared with enterovirus, herpes simplex virus and varicella zoster virus but not West Nile virus.CMV meningoencephalitis occurs most often in patients with HIV and encephalitis occurs more frequently than meningitis. Clinical and laboratory findings differ compared with other viral etiologies and can support consideration of CMV in the differential diagnosis of patients with meningoencephalitis.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
丫头发布了新的文献求助10
刚刚
天真的不评完成签到 ,获得积分10
刚刚
坨子完成签到,获得积分20
1秒前
19880818发布了新的文献求助10
2秒前
Joleneli100发布了新的文献求助10
2秒前
坨子发布了新的文献求助10
4秒前
科目三应助pzzz123采纳,获得10
5秒前
脑洞疼应助平常乐安采纳,获得10
5秒前
6秒前
昏睡的飞机完成签到,获得积分10
7秒前
温暖的夏岚完成签到 ,获得积分10
7秒前
7秒前
8秒前
chaserlife完成签到,获得积分10
9秒前
9秒前
地平完成签到,获得积分10
9秒前
jinyy完成签到,获得积分10
9秒前
量子星尘发布了新的文献求助10
10秒前
yoyo122完成签到,获得积分10
11秒前
ri_290发布了新的文献求助10
11秒前
vousme完成签到 ,获得积分10
12秒前
12秒前
朴实飞松完成签到 ,获得积分10
12秒前
奶酪发布了新的文献求助10
12秒前
xzy998应助弱于一般人类采纳,获得10
13秒前
14秒前
李健的小迷弟应助梅TiAmo采纳,获得10
17秒前
17秒前
123完成签到,获得积分10
17秒前
木子田心发布了新的文献求助10
18秒前
xx发布了新的文献求助10
18秒前
顾矜应助微雨采纳,获得10
18秒前
18秒前
iFan完成签到 ,获得积分10
20秒前
22秒前
blackswan完成签到,获得积分10
22秒前
22秒前
八宝粥完成签到,获得积分10
23秒前
zhangjiegxf发布了新的文献求助10
23秒前
19880818完成签到,获得积分10
24秒前
高分求助中
(禁止应助)【重要!!请各位详细阅读】【科研通的精品贴汇总】 10000
Semantics for Latin: An Introduction 1099
Biology of the Indian Stingless Bee: Tetragonula iridipennis Smith 1000
Robot-supported joining of reinforcement textiles with one-sided sewing heads 740
镇江南郊八公洞林区鸟类生态位研究 500
Thermal Quadrupoles: Solving the Heat Equation through Integral Transforms 500
Corpus Linguistics for Language Learning Research 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4139320
求助须知:如何正确求助?哪些是违规求助? 3676275
关于积分的说明 11620352
捐赠科研通 3370382
什么是DOI,文献DOI怎么找? 1851340
邀请新用户注册赠送积分活动 914489
科研通“疑难数据库(出版商)”最低求助积分说明 829266