代谢组学
癌症
组学
生物信息学
医学
癌症生物标志物
癌细胞
肿瘤科
转化研究
癌症治疗
精密医学
精确肿瘤学
计算生物学
生物标志物
生物
临床试验
个性化医疗
医学物理学
病理
内科学
作者
Daniel R. Schmidt,Rekha C. Patel,David G. Kirsch,Caroline A. Lewis,Matthew G. Vander Heiden,Jason W. Locasale
摘要
Cancer has myriad effects on metabolism that include both rewiring of intracellular metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor microenvironment, and changes in normal tissue metabolism. With the recognition that fluorodeoxyglucose-positron emission tomography imaging is an important tool for the management of many cancers, other metabolites in biological samples have been in the spotlight for cancer diagnosis, monitoring, and therapy. Metabolomics is the global analysis of small molecule metabolites that like other -omics technologies can provide critical information about the cancer state that are otherwise not apparent. Here, the authors review how cancer and cancer therapies interact with metabolism at the cellular and systemic levels. An overview of metabolomics is provided with a focus on currently available technologies and how they have been applied in the clinical and translational research setting. The authors also discuss how metabolomics could be further leveraged in the future to improve the management of patients with cancer.
科研通智能强力驱动
Strongly Powered by AbleSci AI