两亲性
聚合物
甲基丙烯酸酯
共聚物
单体
胶束
磷脂
材料科学
高分子化学
化学工程
药物输送
磷酰胆碱
化学
膜
有机化学
水溶液
工程类
生物化学
作者
Chie Kojima,Tomoka Hirose,Risa Katayama,Akikazu Matsumoto
出处
期刊:Polymers
[Multidisciplinary Digital Publishing Institute]
日期:2021-08-01
卷期号:13 (16): 2805-2805
被引量:1
标识
DOI:10.3390/polym13162805
摘要
2-Methacryloyloxyethyl phosphorylcholine (MPC) polymers have been used as a coating agent on medical devices and as a carrier in drug delivery systems (DDSs). Paclitaxel (PTX) is a water-insoluble anticancer drug whose solubilizer is necessary for administration. Block and random copolymers composed of hydrophilic MPC and butyl methacrylate, named PMB, show different properties, depending on the polymer sequence and MPC content. In the present study, we used amphiphilic MPC polymers comprising hydrophobic dodecyl methacrylate (DMA). The self-assembling properties and PTX solubilization of random and block poly(MPC-co-DMA)s (rPMDs and bPMDs) with different compositions were examined and compared. rPMDs with high DMA content formed large and relatively loose self-assembled structures, which solubilized PTX. However, bPMDs formed small and compact self-assembled structures with poor PTX solubilization. PTX solubilized by PMB with small and loose self-assembled structures showed efficient drug action, similar to free PTX; however, rPMDs fell short of demonstrating PTX efficiency. Our results suggest that the self-assembling properties and the hydrophobicity of amphiphilic MPC polymers largely affect PTX solubilization as well as drug action, which is required to be controlled by the polymer sequence, as well as the structure and composition of the hydrophobic monomer for efficient DDS.
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