化学
点击化学
生物化学
硫醚
化学生物学
化学改性
生物物理学
组合化学
有机化学
生物
作者
Kiall F. Suazo,Keun‐Young Park,Mark D. Distefano
出处
期刊:Chemical Reviews
[American Chemical Society]
日期:2021-04-06
卷期号:121 (12): 7178-7248
被引量:58
标识
DOI:10.1021/acs.chemrev.0c01108
摘要
Protein lipid modification involves the attachment of hydrophobic groups to proteins via ester, thioester, amide, or thioether linkages. In this review, the specific click chemical reactions that have been employed to study protein lipid modification and their use for specific labeling applications are first described. This is followed by an introduction to the different types of protein lipid modifications that occur in biology. Next, the roles of click chemistry in elucidating specific biological features including the identification of lipid-modified proteins, studies of their regulation, and their role in diseases are presented. A description of the use of protein-lipid modifying enzymes for specific labeling applications including protein immobilization, fluorescent labeling, nanostructure assembly, and the construction of protein-drug conjugates is presented next. Concluding remarks and future directions are presented in the final section.
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