间充质干细胞
急性呼吸窘迫综合征
医学
旁分泌信号
干细胞
Wnt信号通路
干细胞疗法
细胞疗法
微泡
癌症研究
炎症
祖细胞
肺
免疫学
生物信息学
病理
信号转导
细胞生物学
生物
内科学
小RNA
受体
生物化学
基因
作者
Zhenxing Wang,Tong Yu,Yapeng Hou,Wei Zhou,Yan Ding,Hongguang Nie
标识
DOI:10.2174/1381612828666220707104356
摘要
Abstract: Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a serious clinical common disease, which may be caused by a variety of pathological factors and can induce a series of serious complications. There is still no specific and effective method for the treatment of ALI/ARDS. Mesenchymal stem cells (MSCs) have been one of the treatment methods for ALI, which can regulate related signal pathways such as PI3K/AKT, Wnt, and NF-κB to reduce inflammation. MSCs exist in a variety of tissues and have the ability of self-renewal and differentiation, which can be activated by specific substances or environments and home to the site of tissue damage, where they differentiate into new tissue cells and repair the damage. Both exosomes and cytokines involving the paracrine mechanism of MSCs have benefits on the treatment of ALI. Lung organoids produced by 3D culture technology can simulate the characteristics of the lung and help to research the pathophysiological process of ALI. This review summarizes the mechanisms by which MSCs treat ALI/ARDS and expects to use 3D models for future challenges in this field.
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