MnFe2O4/MoS2 nanocomposite as Oxidase-like for electrochemical simultaneous detection of ascorbic acid, dopamine and uric acid

• A biosensor for simultaneous detection of ascorbic acid (AA), dopamine (DA) and uric acid (UA). • The nanocomposites of MnFe 2 O 4 /MoS 2 showed high electrocatalytic activity for AA, DA and UA. • MMF nanocomposite with excellent oxidase like activity. • MMF biosensor has very good anti-interference and reproducibility. In this paper, we adopt a one-pot solvothermal synthesis method to prepare MnFe 2 O 4 /MoS 2 nanocomposite (MMF) as an artificial enzyme for simultaneous electrochemical detection of ascorbic acid (AA), dopamine (DA) and uric acid (UA) by screen-printed carbon electrode (SPCE). The exfoliated MoS 2 surface contains numerous S defects and the spinel MnFe 2 O 4 possesses non-homogeneous catalystic properties, high abundance of oxygen vacancies and surface. It provides high adsorption properties through the replacement of cations with large amounts of active clusters on the surface of nano-impurity composites, as well as the high surface activity of MoS 2 . Finally, we found that MMF can effectively and sensitively detect AA, DA and UA, and the peak current increases significantly in a certain scanning speed range. The electrochemical sensing performance of the synthetic nanocomposite for the analytes was better than that of individually synthesized MoS 2 and MnFe 2 O 4 , respectively. The obtained limit of detection (LOD) of MMF for AA, DA and UA were 0.17 mM, 0.41 μM and 0.14 μM, respectively. In addition, the LOD for simultaneous detection of AA, DA and UA were as low as 0.90 mM, 0.16 μM and 3.05 μM, respectively. The prepared MMF showed good anti-interference ability and reproducibility for the analytes sensing.