医学
灼口综合征
口腔粘膜
眼白化病
口腔医学
皮肤病科
口腔健康
疾病
白化病
牙科
儿科
病理
古生物学
生物
作者
José Alcides Almeida de Arruda,Sebastião Silvério Sousa‐Neto,Lucas Guimarães Abreu,Lauren Frenzel Schuch,Vinícius Gomes Souza,Thainara Vitória Lima Alves,Bárbara Martins-Andrade,Sameep S. Shetty,João Luiz Gomes Carneiro Monteiro,Elismauro Francisco Mendonça,Ricardo Alves Mesquita,Gerhilde Callou
标识
DOI:10.1016/j.disamonth.2022.101356
摘要
Chediak-Higashi syndrome (CHS) is an autosomal recessive disorder characterized by leukocytes with giant secretory granules and a myriad of clinical features. However, it is unknown whether oral lesions are part of the syndrome or are refractory to systemic treatment. Herein, we integrated the available data published in the literature on the oral manifestations of individuals with CHS. Searches on PubMed, Web of Science, Embase, Scopus, and LILACS were conducted to identify studies published up to March/2022. The Joanna Briggs Institute tool was used for the critical appraisal of studies. Fourteen articles (21 cases) were detected. The mean age of individuals was 15.9±8.8 years. There was a slight predominance of males (52.4%). The major manifestation was periodontal disease (81%), although ulceration of the oral mucosa (14.3%), gingival/labial abscess (4.8%), and periodontal abscess (4.8%) were also reported. Oral rehabilitation including dental implants (9.5%) was performed after tooth losses due to the poor prognosis of periodontal therapy. CHS is usually diagnosed in an early stage due to its systemic manifestations such as classic oculocutaneous albinism, recurrent infections, and a propensity for bleeding. Oral health providers should be aware of the manifestations of individuals with CHS. Special care, including oral prophylaxis, is indispensable.
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