医学
血液透析
内科学
安慰剂
随机对照试验
双歧杆菌
营养不良
嗜酸乳杆菌
透析
人体测量学
烧心
益生菌
发酵乳杆菌
物理疗法
胃肠病学
乳酸菌
回流
乳酸
病理
细菌
替代医学
遗传学
植物乳杆菌
疾病
生物
作者
Daniela Viramontes-Hörner,Fabiola Márquez-Sandoval,Fabiola Martín-del-Campo,Barbara Vizmanos,Ana Sandoval-Rodriguez,Juan Armendáriz-Borunda,Hector Garcia-Bejarano,Karina Renoirte-Lopez,Guillermo Garcia-Garcia
标识
DOI:10.1053/j.jrn.2014.09.008
摘要
The study aimed to assess the effect of a symbiotic gel on presence and severity of gastrointestinal symptoms (GIS) in hemodialysis patients.A double-blinded, placebo-controlled, randomized, clinical trial was designed. The study was conducted at 2 public hospitals in Guadalajara, Mexico.Twenty-two patients were randomized to the intervention group (nutritional counseling + symbiotic gel) and 20 patients were randomized to the control group (nutritional counseling + placebo), during 2 months of follow-up.Presence and monthly episodes of GIS were assessed by direct interview and severity by using the self-administered GIS questionnaire. Additionally, biochemical parameters, inflammatory markers, and nutritional status (dietary intake, subjective global assessment, anthropometry, and body composition) were evaluated.After a 2-month treatment, intervention group had a significant reduction in prevalence and monthly episodes of vomit, heartburn, and stomachache, as well as a significant decrease in GIS severity compared with control group. Moreover, intervention group had a greater yet not significant decrease in the prevalence of malnutrition and a trend to reduce their C-reactive protein and tumor necrosis factor α levels compared with control group. No symbiotic-related adverse side effects were shown in these patients. Clinical studies with longer follow-up and sample size are needed to confirm these results.We concluded that administration of a symbiotic gel is a safe and simple way to improve common GIS in dialysis patients.
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