CHL1 gene polymorphisms increase lung cancer susceptibility

// Wen Tian 1, 2 , Xuelian Li 1, 2 , Yangwu Ren 1, 2 , Zhihua Yin 1, 2 , Xiaowei Quan 1, 2 , Chang Zheng 1, 2 and Baosen Zhou 1, 2 1 Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China 2 Key Laboratory of Cancer Etiology and Prevention, China Medical University, Liaoning Provincial Department of Education, Liaoning, Shenyang, China Correspondence to: Baosen Zhou, email: bszhou@cmu.edu.cn Keywords: polymorphism; lung cancer; susceptibility; CHL1 Received: September 30, 2017 Accepted: November 16, 2017 Published: January 06, 2018 ABSTRACT Lung cancer represents a complex and malignant cancer. Close Homologue of L1 (CHL1) gene plays a crucial role in the progress of cancer. The aim of this study is to explore the association between CHL1 rs425366 polymorphism and lung cancer susceptibility in northeast of China. A hospital-based case-control study was carried out to collect relative characteristics. Logistic regression analysis was conducted to analyze the relationship between single nucleotide polymorphisms and lung cancer susceptibility. The results suggested that there was statistically significant difference between GT genotype and TT genotype of rs425366 and lung cancer susceptibility. In stratified analysis, TT genotype of rs425366 may increase the risk of lung adenocarcinoma. We also found that non-smoking individuals carrying T allele were more likely to develop lung cancer. Overall, our study may indicate that CHL1 gene may increase lung cancer susceptibility in northeast of China.