海西定
汉普
下调和上调
车站3
红细胞生成
过氧化物还原蛋白
化学
细胞生物学
生物
免疫学
内科学
信号转导
生物化学
炎症
医学
贫血
过氧化物酶
基因
酶
作者
Alessandro Mattè,Luigia De Falco,Enrica Federti,Anna Cozzi,Achille Iolascon,Sonia Levi,Narla Mohandas,Alberto Zamò,Mariasole Bruno,Christophe Lebouef,Anne Janin,Angela Siciliano,Tomas Ganz,Giorgia Federico,Francesca Carlomagno,Sebastian Mueller,Inês Pires da Silva,Carmine Carbone,Davide Melisi,Dae Won Kim
标识
DOI:10.1089/ars.2017.7051
摘要
Collectively, our data highlight a novel role of Prx2 in iron homeostasis. Prx2 is a key cytoprotector against IO that is induced either by iron supplementation or due to chronic hemolysis as in β-thalassemia. Prx2 is required to support STAT3 transcriptional activity and regulation of Hamp expression. Antioxid. Redox Signal. 28, 1-14.
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