PI3K/AKT/mTOR通路
医学
耐受性
mTOR抑制剂的发现与发展
临床试验
依维莫司
替西罗莫司
癌症研究
癌症
西罗莫司
药理学
生物信息学
肿瘤科
信号转导
内科学
生物
不利影响
生物化学
作者
Xiaolin Wan,Lee J. Helman
出处
期刊:Oncologist
[AlphaMed Press]
日期:2007-08-01
卷期号:12 (8): 1007-1018
被引量:177
标识
DOI:10.1634/theoncologist.12-8-1007
摘要
Learning Objectives After completing this course, the reader will be able to: Discuss the function of the mTOR pathway in cancer cell growth and survival.Describe the potential mechanism of targeting this pathway by rapamycin and its derivatives for cancer therapy.Summarize the clinical trials performed with mTOR inhibitors in the treatment of sarcomas and suggest the future clinical development of these inhibitors in the treatment of sarcomas. CME Access and take the CME test online and receive 1 AMA PRA Category 1 Credit™ at CME.TheOncologist.com
科研通智能强力驱动
Strongly Powered by AbleSci AI