脂质体
二棕榈酰磷脂酰胆碱
控制释放
双层
化学工程
自愈水凝胶
磷脂
动力学
化学
药物输送
海藻酸钙
脂质双层
色谱法
钙
材料科学
生物物理学
纳米技术
高分子化学
有机化学
膜
磷脂酰胆碱
生物化学
物理
量子力学
工程类
生物
作者
Martin Ullrich,Jaroslav Hanuš,Jiří Dohnal,František Štĕpánek
标识
DOI:10.1016/j.jcis.2012.11.016
摘要
Composite microparticles consisting of a calcium alginate gel matrix with embedded liposomes made from cholesterol:DPPC (dipalmitoylphosphatidylcholine) mixtures were considered. Factors affecting the encapsulation stability of liposomes during the gel formation by ionic cross-linking – namely temperature and the cholesterol:DPPC ratio – were systematically investigated. The liposomes were found to be tolerant to Ca2+ ions during cross-linking of the gel and stable in the hydrogel matrix for extended periods of time when cholesterol was present in the phospholipid bilayer and temperature was kept sufficiently below the phase transition. The temperature-controlled release rate of encapsulated fluorescent dye was quantified. It is shown that a defined quantity of encapsulated substance can be repeatedly released from the embedded liposomes “on-demand” by short temperature pulses of suitably chosen duration and amplitude. This makes the hydrogel–liposome composites potential candidates for applications such as controlled drug delivery or study of reaction–diffusion phenomena in compartmentalised systems.
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