钆
脂质体
磁共振成像
材料科学
表面改性
纳米技术
纳米颗粒
螯合作用
体内
生物医学工程
壳聚糖
紧固件
核磁共振
生物物理学
化学
生物化学
医学
放射科
生物技术
物理化学
冶金
物理
生物
作者
Clint Smith,Artem Shkumatov,Sarah G. Withers,Binxia Yang,James F. Glockner,Sanjay Misra,Edward J. Roy,Ching-Ping Wong,Steven C. Zimmerman,Hyunjoon Kong
出处
期刊:ACS Nano
[American Chemical Society]
日期:2013-10-11
卷期号:7 (11): 9599-9610
被引量:45
摘要
Common methods of loading magnetic resonance imaging (MRI) contrast agents into nanoparticles often suffer from challenges related to particle formation, complex chemical modification/purification steps, and reduced contrast efficiency. This study presents a simple, yet advanced process to address these issues by loading gadolinium, an MRI contrast agent, exclusively on a liposome surface using a polymeric fastener. The fastener, so named for its ability to physically link the two functional components together, consisted of chitosan substituted with diethylenetriaminepentaacetic acid (DTPA) to chelate gadolinium, as well as octadecyl chains to stabilize the modified chitosan on the liposome surface. The assembly strategy, mimicking the mechanisms by which viruses and proteins naturally anchor to a cell, provided greater T1 relaxivity than liposomes loaded with gadolinium in both the interior and outer leaflet. Gadolinium-coated liposomes were ultimately evaluated in vivo using murine ischemia models to highlight the diagnostic capability of the system. Taken together, this process decouples particle assembly and functionalization and, therefore, has considerable potential to enhance imaging quality while alleviating many of the difficulties associated with multifunctional particle fabrication.
科研通智能强力驱动
Strongly Powered by AbleSci AI