壳聚糖
化学
柠檬酸
双氯芬酸钠
盐酸
核化学
药物输送
钠
水溶液
乳酸
海藻酸钠
色谱法
有机化学
生物
细菌
遗传学
作者
Isabella Orienti,Teresa Cerchiara,Barbara Luppi,Federica Bigucci,Guendalina Zuccari,Vittorio Zecchi
标识
DOI:10.1016/s0378-5173(02)00060-1
摘要
Chitosan (CH) was dissolved in aqueous solutions containing aspartic, glutamic, hydrochloric, lactic and citric acids to obtain different chitosan salts. Chitosan salts were collected from the solutions by spray-drying and the powders obtained were mixed with Sodium Diclofenac (SD), taken as a model anti-inflammatory drug. This study evaluated in vitro the influence of acid type on the release behaviour of SD from the physical mixture during gastrointestinal transit. The physical mixture of the chitosan salts with SD provided slower drug release than the pure drug both in acidic and alkaline pHs. In addition, the interaction with beta-glucosidase at pH 7.0 enhanced the release rate. Among the CH salts used, glutamic and aspartic salts provided the best control of release.
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