去卵巢大鼠
内分泌学
内科学
毒蕈碱乙酰胆碱受体
卡巴胆碱
雌激素
排尿
受体
逼尿肌
雌激素受体
医学
膀胱
化学
泌尿系统
癌症
乳腺癌
作者
Willmann Liang,Karoush Afshar,Lynn Stothers,Ismail Laher
出处
期刊:Life Sciences
[Elsevier]
日期:2002-06-01
卷期号:71 (3): 351-362
被引量:42
标识
DOI:10.1016/s0024-3205(02)01645-4
摘要
A rat model of ovariectomy-induced voiding dysfunction was established and the effects of ovariectomy and subsequent estrogen replacement on the affinity of muscarinic receptors in the rat bladder were determined. Voiding frequency and spatial distribution patterns were documented in sham-operated (control), and ovariectomized (placebo- or estrogen-treated) rats. The ovariectomized rats had a significantly different urinating pattern, i.e. higher voiding frequency and less peripheral voiding than the sham-operated group, suggestive of urge incontinence. Using this model of voiding dysfunction, negative logs of dissociation constants of carbachol of the rat detrusor muscarinic receptors were then determined indirectly using the Furchgott's double-reciprocal method. Receptor affinities were not significantly different in all groups compared to control females. In conclusion, a model of ovariectomy-induced voiding dysfunction in ovariectomized rats was established, where bladder dysfunction occurred with no significant changes in the affinity of muscarinic receptors.
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