内质网
细胞生物学
线粒体
细胞器
生物发生
膜接触部位
功能(生物学)
化学
细胞器生物发生
生物
生物化学
膜蛋白
基因
膜
整体膜蛋白
作者
Ashley A. Rowland,Gia K. Voeltz
摘要
The most well-characterized organelle contact sites are those between the endoplasmic reticulum (ER) and mitochondria. Increased understanding is being gained of how ER-mitochondria contact sites are organized and which factors converge at this interface, some of which may provide a tethering function. The role of the ER-mitochondria junction in coordinating the functions of these two organelles is also becoming clearer, and it has been shown to be involved in the regulation of lipid synthesis, Ca(2+) signalling and the control of mitochondrial biogenesis and intracellular trafficking.
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