Abstract Flaked cottonseed was extracted with chloroform‐methanol‐water, chloroform‐methanol, hexane‐acetone‐water, hexane‐acetone, hexane and acetone. Amounts of total material in the miscellae were greatest with chloroform‐methanol‐water and decreased to acetone in the order given above. The first three solvents extracted 6% more neutral oil and over 100% more lipophilic phosphorus than the latter three solvents. All solvents showed similar rates of extraction, each removed over 70% of extractables with the first of four passes.