斑马鱼
达尼奥
生物
造血
模式生物
血细胞
遗传筛选
细胞生物学
突变体
干细胞
遗传学
基因
作者
Jill L. O. de Jong,Leonard I. Zon
出处
期刊:Annual Review of Genetics
[Annual Reviews]
日期:2005-12-01
卷期号:39 (1): 481-501
被引量:250
标识
DOI:10.1146/annurev.genet.39.073003.095931
摘要
The zebrafish (Danio rerio) has emerged as an ideal organism for the study of hematopoiesis, the process by which all the cellular elements of the blood are formed. These elements, including erythrocytes, granulocytes, monocytes, lymphocytes, and thrombocytes, are formed through complex genetic signaling pathways that are highly conserved throughout phylogeny. Large-scale forward genetic screens have identified numerous blood mutants in zebrafish, helping to elucidate specific signaling pathways important for hematopoietic stem cells (HSCs) and the various committed blood cell lineages. Here we review both primitive and definitive hematopoiesis in zebrafish, discuss various genetic methods available in the zebrafish model for studying hematopoiesis, and describe some of the zebrafish blood mutants identified to date, many of which have known human disease counterparts.
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