间质细胞
免疫系统
癌症免疫疗法
白细胞介素17
免疫疗法
癌症研究
肿瘤微环境
细胞因子
炎症
癌细胞
癌症
背景(考古学)
免疫学
生物
细胞毒性T细胞
白细胞介素12
医学
体外
内科学
古生物学
生物化学
标识
DOI:10.1007/s12272-019-01146-9
摘要
Th17 cells are a specialized subset of CD4+ T cells that are essential in driving inflammation during autoimmune disease and infection through a signature cytokine IL-17. Th17 cells have been found in various human cancers. The function of these cells in cancers is highly context-dependent; both tumor-promoting and tumor-suppressing activity have been reported. IL-17 and IL-22, Th17-derived cytokines, influence the tumor microenvironment by directly promoting transformed cell properties and neighboring stromal cell activity. These cytokines are also involved in regulation of the immune system by modulating the activities of myeloid cells and T cells. These findings suggest that Th17 cells and their cytokines are a key mediator of cancer development, representing a potential target for cancer therapy. Herein, I review recent preclinical studies on the function of Th17 cells and IL-17 in cancer and discuss possible therapeutic approaches to harness Th17 cells for cancer immunotherapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI